Examination of industrially significant biotechnologies. Batch, continuous flow and fixed media reactor designs, downstream processing and refining of biological compounds are explored. Students participate in the entire production process, assessing how the critical steps of capture, purification and final polishing of biomolecules are achieved in production scale operations. Study of the equipment, materials and practices involved in commercial scale operations that use or produce biological elements. Material transport, scaling of unit operations, clean room practices and material properties will be explored. This course includes site visits to industrial production facilities.